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KMID : 0617220020130010069
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Duksung Bulletin Phamaceutical Sciences
2002 Volume.13 No. 1 p.69 ~ p.74
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Synthesis of 4,5-substituted 3-alkoxy-6-allylthiopyridazine Derivatives
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Abstract
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Through a modification of allicin structure a disagreeable odor and chemical instability of allicin can be improved. 3-Alkoxy-6-allylthiopyridazine derivatives exhibit a superior effect for prevention and treatment of hepatic diseases induced by carbon tetrachloride and aflatoxin B1 and for prevention of human tissues from radiation. These compounds inhibit also efficiently SK-Hep-1 cell proliferation through induction of apoptosis. So another 4,5-mono-or di-substituted 3-alkyloxy-6-allythiopyridazine derivatives were synthesized on purpose to find out SAR of allylthiopyridazine in hepatoprotective and hepatotherapeutic acitivitis and to develop more effective drug candidate.
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